Key result
Serum 25(OH)D shows no independent association with the TC/HDL ratio in established CAD.
Why the study?
Vitamin D deficiency is associated with coronary artery disease, but its association with lipid profiles in established CAD needed evaluation.
Is serum 25(OH)D deficiency associated with adverse lipid biomarkers in patients with established coronary artery disease?
Cross-Sectional (n=73)
Is serum 25(OH)D deficiency associated with adverse lipid biomarkers in patients with established coronary artery disease?
Answers are grounded in this paper and cite their sources.
Vitamin D deficiency is highly prevalent in young to middle-aged patients with established CAD and correlates negatively with the TC/HDL ratio, though independent association was not confirmed in multivariate analysis.
Objectives Vitamin D deficiency (VDD) is associated with coronary artery disease (CAD) directly by augmenting atherosclerosis and indirectly through cardiovascular risk factors. The present study was aimed to find an association of 25 hydroxyvitamin D (25(OH)D) with lipid profile among established CAD. Methods A cross-sectional study was conducted among 73 patients of angiographically confirmed CAD aged between 35 and 55 years of both gender. Serum 25(OH)D and lipid profile were estimated by ELISA kit and Roche autoanalyzer respectively. Atherogenic index of plasma (AIP) and sdLDL (small dense low-density lipoprotein) were calculated using the accepted formula. Results The mean 25(OH)D level was 17.95 ± 13.51. Only 15% had sufficient 25(OH)D level. There was a significant negative correlation of 25(OH)D with TC/HDL (T.cholesterol/High-density lipoprotein) ratio (p=0.022). Multivariate logistic regression analysis showed no statistically significant impact of 25(OH)D with lipid biomarkers. Conclusions We found low 25(OH)D mean value among CAD and a significant negative correlation of 25(OH)D with TC/HDL. This study suggests VDD may affect primary lipid target resulting in unfavorable outcomes in CAD.
No takes yet. Share an insight, caveat, or question.
Yassir et al. (2021) conducted a cross-sectional in Coronary artery disease (n=73). Serum 25 hydroxyvitamin D levels was evaluated on Association of 25(OH)D with lipid profile (TC/HDL ratio) (p=0.022). Serum 25(OH)D levels showed a significant negative correlation with the TC/HDL ratio (p=0.022) in patients with established CAD, but no significant impact in multivariate analysis.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: