What question did this study set out to answer?

To determine whether the essential amino acid lysine serves as a metabolic precursor for carnitine biosynthesis in rats.

October 1, 1971Journal of Biological ChemistryOpen Access

Lysine, a Precursor of Carnitine in the Rat

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Authors

VTVichai TanphaichitrSiriraj Hospital DHDonald W. HorneVanderbilt University HBHarry P. BroquistUtah State University

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Implication

Animal tracer study reveals incorporation of radiolabeled lysine into carnitine in rats, demonstrating an essential precursor role of lysine in endogenous carnitine biosynthesis.

Key Points

To determine whether the essential amino acid lysine serves as a metabolic precursor for carnitine biosynthesis in rats.
Maintained rats on a 20% gluten diet deficient in lysine with or without 0.8% supplemental lysine.
Administered intraperitoneal dl-[6-14C]lysine or dl-[2-14C]lysine to lysine-deficient rats to trace radiolabel incorporation into tissue carnitine.
Lysine deficiency caused growth reduction, anemia, hypoproteinemia, significantly lower carnitine concentrations in skeletal muscle and heart, and higher carnitine concentrations in liver relative to lysine-supplemented rats.
Radioactivity from dl-[6-14C]lysine, but not dl-[2-14C]lysine, was significantly incorporated into carnitine in skeletal muscle and liver.

Cite This Study

Tanphaichitr et al. (1971) studied this question.

synapsesocial.com/papers/6aa4a1e827d245a4842bc459 https://doi.org/10.1016/s0021-9258(18)61799-5

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Implication

Animal tracer study reveals incorporation of radiolabeled lysine into carnitine in rats, demonstrating an essential precursor role of lysine in endogenous carnitine biosynthesis.

Lysine, a Precursor of Carnitine in the Rat

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Implication

Key Points

Cite This Study

Lysine, a Precursor of Carnitine in the Rat

Discussion

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Implication

Key Points

Cite This Study

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