Association Between Cardiovascular Risk Profiles and the Presence and Extent of Different Types of Coronary Atherosclerotic Plaque as Detected by Multidetector Computed Tomography
Key result
Hyperlipidemia and family history of CAD are linked to greater noncalcified coronary plaque extent.
- P=0.02
- n=195
Why the study?
Are cardiovascular risk factors associated with the extent of different types of coronary atherosclerotic plaque detected by MDCT in patients with chest pain?
Population
195 consecutive subjects presenting with chest pain but no history of coronary artery disease and who did…
Design
Cross-sectional
Authors
Discussion
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Implication
Does not support changing chest pain evaluation; hypothesis-generating for hyperlipidemia and noncalcified plaque on MDCT.
Study Design
Type
Cross-Sectional (n=195)
Structured PICO
Are cardiovascular risk factors associated with the extent of different types of coronary atherosclerotic plaque detected by MDCT in patients with chest pain?
P
Population
195 patients (mean age 54.6, 46.7% female) presenting with chest pain but no history of CAD or acute coronary syndrome.
E
Exposure
Contrast-enhanced 64-slice coronary MDCT
O
Outcome
Presence and extent of noncalcified (NCAP), mixed (MCAP), and calcified coronary atherosclerotic plaque (CAP) for each coronary segmentsurrogate
Main Result
p-value: p=0.02
Hyperlipidemia and family history of CAD are associated with the extent of noncalcified coronary plaque on MDCT in patients with chest pain.
Limitations
- Requires confirmation in larger observational trials
- Small sample size requiring larger observational trials to confirm findings
Cite This Study
Bamberg et al. (2008) conducted a cross-sectional in chest pain without history of CAD or acute coronary syndrome (n=195). Cardiovascular risk factors (hyperlipidemia, family history of CAD) was evaluated on extent of noncalcified coronary atherosclerotic plaque (NCAP) (p=0.02). Hyperlipidemia and family history of CAD were associated with the extent of noncalcified coronary atherosclerotic plaque (P=0.02 and P=0.04, respectively).