Prognostic impact of electrocardiographic signs in patients with Type 2 diabetes and cardiovascular disease: results from the PROactive study
Key result
Baseline electrocardiographic signs, including right (4.1%) and left (2.1%) bundle branch blocks, heart rate, and cQT-interval, were independently predictive of mortality and heart failure.
Why the study?
Do baseline electrocardiographic signs predict mortality and cardiovascular events in patients with Type 2 diabetes and cardiovascular disease?
Population
5,231 patients with Type 2 diabetes and cardiovascular disease (participants of the PROactive trial)
Comparison
Presence of baseline electrocardiographic signs vs Absence of these electrocardiographic signs or…
Design
Cohort
Authors
Discussion
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Implication
May refine risk stratification in type 2 diabetes with CVD; leaves open whether ECG-guided interventions alter outcomes.
Study Design
Type
Cohort (n=5,231)
Structured PICO
Do baseline electrocardiographic signs predict mortality and cardiovascular events in patients with Type 2 diabetes and cardiovascular disease?
P
Population
5,231 patients with Type 2 diabetes and cardiovascular disease from the PROactive trial with available baseline 12-lead electrocardiographs.
E
Exposure
Presence of baseline electrocardiographic signs (heart rate, cQT-interval, atrial fibrillation/flutter, left axis deviation, right and left bundle branch block)
C
Comparator
Absence of these electrocardiographic signs or continuous comparison (for heart rate and cQT-interval)
O
Outcome
Total mortality, principal secondary composite endpoint (death, myocardial infarction, and stroke), and serious adverse heart failure eventshard clinical
Easily assessable baseline ECG signs, including heart rate, cQT-interval, and bundle branch blocks, independently predict adverse cardiovascular outcomes and mortality in patients with Type 2 diabetes and cardiovascular disease.
Cite This Study
Pfister et al. (2011) conducted a cohort in Type 2 diabetes and cardiovascular disease (n=5,231). Electrocardiographic signs was evaluated on Total mortality, composite secondary endpoint (death, myocardial infarction and stroke), and serious adverse heart failure events. Baseline electrocardiographic signs, including right (4.1%) and left (2.1%) bundle branch blocks, heart rate, and cQT-interval, were independently predictive of mortality and heart failure.