Key result
High oxygen partial pressures induce seizures and decrease striatal dopamine release in rats.
High-pressure oxygen exposure induces central nervous system disturbances, including epileptic seizures and altered dopamine release, likely mediated by reactive oxygen and nitrogen species.
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Hyperoxia may pose CNS risks in therapy; leaves open translation of rat dopamine findings to human cardiovascular practice.
All mammals, including man, exposed to breathing gas mixtures at high pressures exhibit central nervous system disturbances, which differ according to the gas used. With the use of compressed air, the increased oxygen partial pressure induces hyperoxic disturbances that consist of epileptic seizures that occur, on average, after 30 min exposure to 2.8 ATA in man or to 5 ATA in rats. Increased oxygen partial pressure induces reactive oxygen species and reactive nitrogen species production that could be related to neurotransmitter changes reported for the preepileptic phase or at pressures that produce epileptic seizures. In rats, oxygen pressures lower than 5 ATA induce a decrease of dopamine release in the stratum that could be due to disturbances of neurotransmitter regulatory processes that are different from those implicated for hyperbaric oxygen‐induced epileptic seizures.
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Rostain et al. (2016) conducted a review in Oxygen toxicity. High pressure oxygen was evaluated on Central nervous system disturbances and dopamine release. Exposure to high oxygen partial pressures induces hyperoxic disturbances such as epileptic seizures, and pressures lower than 5 ATA decrease striatal dopamine release in rats.
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