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November 1, 2017EuroIntervention

Dual antiplatelet therapy after acute coronary syndromes: no time for a CHANGE

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Why the study?

Does ticagrelor reduce the composite of cardiac death, myocardial infarction and stroke compared with clopidogrel in patients with acute coronary syndrome undergoing percutaneous coronary intervention?

Population

Patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention

Comparison

Ticagrelor vs Clopidogrel

Design

Editorial

Key result

This editorial discusses recent evidence questioning the role of ticagrelor as a first-line antiplatelet option in patients with acute coronary syndromes undergoing percutaneous coronary intervention.

Authors

DCDavide Capodanno

Discussion

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Member takes

Overview

Questions ticagrelor first-line role in ACS-PCI; leaves open whether recent data warrant guideline revision.

Structured PICO

Does ticagrelor reduce the composite of cardiac death, myocardial infarction and stroke compared with clopidogrel in patients with acute coronary syndrome undergoing percutaneous coronary intervention?

P
Population
Patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention
I
Intervention
Ticagrelor
C
Comparator
Clopidogrel
O
Outcome
Composite of cardiac death, myocardial infarction and strokecomposite

An editorial discussing recent evidence that questions the guideline-recommended role of ticagrelor as a first-line antiplatelet option in ACS patients undergoing PCI.

Cite This Study

Davide Capodanno (2017) conducted an editorial in Acute coronary syndrome (ACS). Prasugrel and ticagrelor (Dual antiplatelet therapy) vs. Clopidogrel was evaluated on Composite of cardiac death, myocardial infarction and stroke. This editorial discusses recent evidence questioning the role of ticagrelor as a first-line antiplatelet option in patients with acute coronary syndromes undergoing percutaneous coronary intervention.

synapsesocial.com/papers/6aa4a6012fdbcb5be994df56https://doi.org/10.4244/eijy17m08_01
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dual Antiplatelet Therapy in Coronary Artery Disease2020 · 46 citations
  2. 2Oral antiplatelet therapy in acute coronary syndromes: update 20122012 · 10 citations
  3. 3Antiplatelet options for secondary prevention in acute coronary syndromes2011 · 3 citations
  4. 4Modern Antiplatelet Therapy for Percutaneous Coronary Intervention. How to Make the Right Choice?2020 · 1 citations
  5. 5A Review of the Role of the Antiplatelet Drug Ticagrelor in the Management of Acute Coronary Syndrome, Acute Thrombotic Disease, and Other Diseases2022 · 13 citations