Key result
Adding a social risk score to FRS modestly improves CVD prediction independent of traditional risk factors.
Why the study?
The Framingham risk score is widely used to predict CVD but neglects social risk factors, leaving unclear whether adding a cumulative social risk score improves prediction.
Does the addition of a cumulative social risk score to the Framingham risk score improve the prediction of cardiovascular disease in South Korean adults?
Cross-Sectional
Does the addition of a cumulative social risk score to the Framingham risk score improve the prediction of cardiovascular disease in South Korean adults?
Incorporating cumulative social risk factors into traditional risk models like the Framingham risk score significantly improves the prediction of cardiovascular diseases, highlighting the independent impact of social determinants of health.
INTRODUCTION: The Framingham risk score (FRS) is widely used to predict cardiovascular disease (CVD), but it neglects to account for social risk factors. Our study examined whether use of a cumulative social risk score in addition to the FRS improves prediction of CVD among South Korean adults. METHODS: and area under receiver operating characteristic curve (AUC) assessed model performance. We conducted mediation analyses to quantify the association between cumulative social risk score and CVD outcomes that is not mediated by the FRS. RESULTS: and AUC by 2.4% and 0.039. In the association between cumulative social risk and stroke, the proportion not mediated by the FRS was 65% (P < .001). We observed similar trends in myocardial infarction and angina, such that an increase in social risk was associated with increased relative risk of disease and improved disease diagnosis, and a large proportion of the association was not mediated by the FRS. CONCLUSION: Controlling for the FRS, cumulative social risks predicted stroke, myocardial infarction, and angina among adults in South Korea. Future research is needed to examine non-FRS mediators between cumulative social risk and CVD.
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Lee et al. (2020) conducted a cross-sectional in Cardiovascular disease. Cumulative social risk score vs. Framingham risk score alone was evaluated on Prediction of cardiovascular disease (stroke, myocardial infarction, and angina) (p=<.001). Adding a cumulative social risk score to the Framingham risk score improved cardiovascular disease prediction (AUC increased by 0.039), with 65% of the stroke association not mediated by FRS (P<.001).
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