Synthesis and anti-inflammatory activity of some new 1,3,4-thiadiazoles containing pyrazole and pyrrole nucleus

A new series of 1,3,4-thiadiazole with pyrazole-3-carboxamides ( 3a – f ) and pyrrole-3-carboxamide ( 4a – f ) moiety are prepared using intermediate compounds 1,3,4-thiadiazolacrylamides ( 2a – f ). The structures of newly synthesized compounds were confirmed on the basis of their 1 H NMR, 13 C NMR, LCMS mass, FT-IR and elemental analysis data results. Among all the compounds (12), seven compounds were found to exhibit significant anti-inflammatory activity with 77.27, 75.89, 76.24, 68.55, 63.72, 57.41, 53.05% and 81.00, 80.55, 78.62, 71.45, 68.95, 61.89, 56.32% inhibition in paw edema at 3 h and 5 h respectively, compared to the standard drug indomethacin (74.82 and 80.32% at 3 h and 5 h). Compounds 3c, 3d and 4c exhibited potent activity than standard drug.