Key result
NSAIDs are associated with an increased risk of serious gastrointestinal and cardiovascular adverse events, which may be mitigated by dose reduction but require further study for predictive markers.
Population
Patients with rheumatoid arthritis and osteoarthritis
Design
Review
Authors
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NSAID prescribing warrants dose minimization to limit GI/CV risks; leaves open validation of predictive markers for safer use.
NSAID use requires careful dose management due to inherent gastrointestinal and cardiovascular risks, with a future need for predictive genetic or biochemical markers.
Patrignani et al. (2011) conducted a review in Rheumatoid arthritis and osteoarthritis. NSAIDs (traditional and selective COX-2 inhibitors) was evaluated. NSAIDs are associated with an increased risk of serious gastrointestinal and cardiovascular adverse events, which may be mitigated by dose reduction but require further study for predictive markers.
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