Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 3, 2024Journal of Nepal Health Research CouncilOpen Access

Risk Factors and Clinico-laboratory Characteristics of Scrub Typhus in Children Admitted to a Tertiary Pediatric Hospital of Nepal

View Full Paper
Ask AI
Bookmark
Share

Authors

RCRam Hari ChapagainGovernment of NepalSASantosh AdhikariTribhuvan UniversityBBBihungum BistaNepal Health Research Council

Discussion

Loading...

Member takes

Implication

Case-control study identifies environmental exposures, hepatomegaly, and thrombocytopenia in pediatric scrub typhus, highlighting the role of rural living conditions in infection risk.

Key Points

  • To identify risk factors, clinical characteristics, laboratory profiles, and treatment outcomes among hospitalized pediatric patients presenting with scrub typhus.
  • Conducted a case-control study from 2021 to September 2023 at a tertiary government pediatric referral hospital in central Nepal.
  • Enrolled 137 pediatric patients presenting with acute febrile illness, comprising 68 confirmed scrub typhus cases (diagnosed via antibody rapid testing) and 69 age-, sex-, and residence-matched febrile controls without chronic illness.
  • Common clinical and laboratory features among cases included fever (98.5%, n=67), hepatomegaly (50.0%, n=34), lymphadenopathy (29.4%, n=20), splenomegaly (27.9%, n=19), eschar (17.6%, n=12), thrombocytopenia (51.5%, n=35), and leukocytosis (32.3%, n=22).
  • Complications arose in 20.6% (n=14) of cases, and 17.6% (n=12) required intensive care; following therapy, fever resolved within 24 hours in 46.3% (n=31) and within 48 hours in 29.8% (n=20).
  • Environmental and behavioral exposures associated with cases included napping on the ground (80%), residing in non-cemented homes (72% increased risk), nearby brush (62%), and indoor animal exposure (63%).

Cite This Study

Chapagain et al. (2024) studied this question.

synapsesocial.com/papers/6aa4a90b997531f89014276ahttps://doi.org/10.33314/jnhrc.v22i02.5177
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Epidemiologic, clinical and laboratory features of scrub typhus in thirty Thai children2003 · 120 citations
  2. 2Scrub typhus in rural Rajasthan and a review of other Indian studies2015 · 11 citations
  3. 3Clinical profile, complications, outcome and predictors of intensive care for paediatric scrub typhus: a tertiary hospital-based study from Southern Rajasthan, India2024
  4. 4Prevalence, Clinico-Laboratory Features and Outcomes of Paediatric Scrub Typhus Cases in a Tertiary Care Centre in Eastern India2024 · 5 citations
  5. 5Scrub typhus in a primary health care center of Nepal: A case series2022 · 5 citations