Key result
Coronary sinus C-type natriuretic peptide levels were significantly higher than femoral artery and peripheral vein levels (3.2 vs 2.6 and 2.5 pg/ml, p<0.001), indicating myocardial production.
Why the study?
Does rapid RA pacing or EPS/RF ablation alter the production or release of C-type natriuretic peptide in patients with normal left ventricular systolic function?
Observational (n=19)
Does rapid RA pacing or EPS/RF ablation alter the production or release of C-type natriuretic peptide in patients with normal left ventricular systolic function?
The myocardium continuously produces or releases C-type natriuretic peptide in individuals with normal LV systolic function, and this is not altered by brief periods of rapid atrial pacing or electrophysiological studies.
Answers are grounded in this paper and cite their sources.
Myocardial CNP production occurs in normal LV function without alteration by brief pacing; leaves open clinical relevance and effects of sustained interventions.
OBJECTIVE: The objective of this study was to evaluate production or release of CNP in individuals without CHF. METHODS: Nineteen patients with symptomatic paroxysmal supraventricular tachycardia (PSVT) and normal left ventricular systolic function were enrolled into the study. Blood samples were collected from the coronary sinus (CS), the femoral artery (FA), and the peripheral vein (PV) before pacing, after rapid RA pacing, and post electrophysiological study (EPS) and/or radiofrequency (RF) ablation. RESULTS: The CNP level in the CS, compared to FA and PV, was significantly higher before pacing (CS, 3.2+/-0.8; FA, 2.6+/-0.7; PV, 2.5+/-0.5 pg/ml; CS vs. either FA or PV, both p<0.001), after the pacing (CS, 3.2+/-1.3; FA, 2.4+/-0.6 pg/ml; p=0.004), and post the EPS and/or RF ablation (CS, 3.1+/-0.7; FA, 2.6+/-0.9; PV, 2.5+/-0.8 pg/ml; CS vs. either FA or PV, both p<0.01). CONCLUSION: The myocardium regularly produces or releases CNP in patients with normal LV systolic function. Brief periods of rapid RA pacing, PSVT, or EPS does not change the production and/or release.
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Kuo et al. (2007) conducted an observational in Symptomatic paroxysmal supraventricular tachycardia (PSVT) with normal left ventricular systolic function (n=19). Coronary sinus blood sampling vs. Femoral artery and peripheral vein blood sampling was evaluated on C-type natriuretic peptide (CNP) level before pacing (pg/ml) (p=<0.001). Coronary sinus C-type natriuretic peptide levels were significantly higher than femoral artery and peripheral vein levels (3.2 vs 2.6 and 2.5 pg/ml, p<0.001), indicating myocardial production.
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