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June 1, 1997Fertility and SterilityOpen Access

Seminal reactive oxygen species and sperm motility and morphology in men with spinal cord injury

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Authors

OPOsvaldo PadronNBNancy L. BrackettRSRakesh Sharma

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Overview

Cross-sectional study finds elevated seminal reactive oxygen species linked to reduced sperm motility in men with spinal cord injury, highlighting oxidative stress in neurogenic infertility.

Key Points

  • To evaluate the generation of seminal reactive oxygen species and examine their relationship with semen parameters in men with spinal cord injury.
  • Conducted a cross-sectional study comparing semen samples from men with spinal cord injury against healthy control donors.
  • Obtained ejaculates via electroejaculation or penile vibratory stimulation in the spinal cord injury group and via masturbation in controls.
  • Assessed reactive oxygen species before and after chemical stimulation (FMLP and PMA), white blood cell concentration, sperm motility, and morphology across antegrade and retrograde specimens.
  • Men with spinal cord injury showed significantly higher levels of reactive oxygen species in unstimulated, FMLP-stimulated, and PMA-stimulated semen compared with controls.
  • Sperm motility was inversely related to reactive oxygen species concentrations, and the percentage of morphologically normal spermatozoa was significantly lower in men with spinal cord injury.
  • White blood cell concentrations were significantly elevated in men with spinal cord injury, while reactive oxygen species levels did not significantly differ by ejaculation method or specimen type.

Cite This Study

Padron et al. (1997) studied this question.

synapsesocial.com/papers/6aa4ab34c19a1092ac81197ehttps://doi.org/10.1016/s0015-0282(97)81448-3
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Analysis of the relationship between reactive oxygen species production and leucocyte infiltration in fractions of human semen separated on Percoll gradients1990 · 277 citations
  2. 2Generation of Reactive Oxygen Species, Lipid Peroxidation, and Human Sperm Function1989 · 1,234 citations
  3. 3Lipid peroxidation in human spermatozoa as relatd to midpiece abnormalities and motility1989 · 312 citations