Key result
Intraventricular conduction defects are linked to a worse ~46% five-year survival rate versus matched controls.
Why the study?
Does the presence of intraventricular conduction defects (LBBB or RBBB with axis deviation) reduce survival compared to age- and sex-matched controls?
Cohort (n=325)
No
Does the presence of intraventricular conduction defects (LBBB or RBBB with axis deviation) reduce survival compared to age- and sex-matched controls?
Patients with intraventricular conduction defects (LBBB or RBBB with axis deviation) have significantly reduced 5-year survival compared to matched controls, highlighting the prognostic importance of these ECG findings.
Answers are grounded in this paper and cite their sources.
Intraventricular conduction defects warrant prognostic caution on ECG review; leaves open independent risk after comorbidity adjustment in contemporary cohorts.
All 42,000 electrocardiograms taken at the University of Oregon Health Sciences Center from 1969 through 1971 were reviewed; 325 patients (0.77%) had left bundle-branch block (LBBB) or right bundle-branch block (RBBB) with axis deviation (AD). In December 1974, 90% were contacted or found to be dead. The five-year survival rate (actuarial technique) (mean ± SE) was 45.5 ± 2.9%. It was significantly worse than that of age- and sex-matched "controls." In most patients the cause of death could not be determined. Survival of 164 LBBB patients (40.7 ± 4.1%) at five years was not significantly worse than that of 161 RBBB and AD patients (49.5 ± 4.2%). Those with syncope did no worse in terms of survival than did those without. The five-year survival in coronary artery disease patients was 33.7 ± 4.4%; in those with primary conduction system disease (20% of patients), it was 50.6 ± 6.6%. It will be necessary to know the causes of death and of syncope in conduction disease patients before it can be determined whether or not pacemakers can prevent either. (Arch Intern Med138:30-35, 1978)
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John H. McAnulty (1978) conducted a cohort in Intraventricular conduction defects (n=325). Intraventricular conduction defects (LBBB or RBBB with axis deviation) vs. Age- and sex-matched controls was evaluated on Five-year survival rate. Patients with intraventricular conduction defects had a five-year survival rate of 45.5%, which was significantly worse than age- and sex-matched controls.
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