A novel enzymatic procedure for the oxidative deprotection of p‐methoxyphenyl (PMP)‐protected amines is described. By using laccases (E.C. 1.10.3.2) under mildly acidic conditions, a variety of PMP‐protected amines were successfully deprotected. The rate of deprotection was solvent‐ and pH‐dependent, and the reaction scope could be increased by using so‐called mediators.
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Verkade et al. (2007) studied this question.
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