The optimal threshold of high post-treatment platelet reactivity could be defined by a point-of-care VerifyNow P2Y12 assay
Key result
VerifyNow PRU ≥ 239 optimally predicts high post-treatment platelet reactivity on LTA.
- AUC 0.794
- 95% CI 0.736-0.851
- P<0.001
- n=300
Why the study?
Does the VerifyNow P2Y12 assay correlate with light transmittance aggregometry for identifying high post-treatment platelet reactivity in patients undergoing PCI with DES?
Population
300 consecutive patients undergoing percutaneous coronary intervention with drug-eluting stent implantation
Comparison
Point-of-care VerifyNow P2Y12 assay vs 5 μM ADP-induced light transmittance aggregometry
Design
Cohort
Authors
Discussion
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Member takes
Implication
VerifyNow PRU ≥239 moderately predicts high LTA reactivity; leaves open whether this threshold improves PCI risk stratification or outcomes.
Structured PICO
Does the VerifyNow P2Y12 assay correlate with light transmittance aggregometry for identifying high post-treatment platelet reactivity in patients undergoing PCI with DES?
P
Population
300 consecutive patients undergoing PCI with DES implantation evaluated for clopidogrel responsiveness using both VerifyNow and LTA.
E
Exposure
Point-of-care VerifyNow P2Y12 assay
C
Comparator
5 μM ADP-induced light transmittance aggregometry (LTA)
O
Outcome
Optimal cut-off of VerifyNow PRU for predicting high post-treatment platelet reactivity (HPPR) on LTA (>50% aggregation)surrogate
Main Result
Effect estimate: AUC 0.794 (95% CI 0.736-0.851)
p-value: p=<0.001
A VerifyNow PRU value ≥ 239 significantly correlates with high post-treatment platelet reactivity on standard light transmittance aggregometry, supporting its use as a point-of-care alternative for risk stratification.
Cite This Study
Jeong et al. (2008) conducted a letter in Patients undergoing PCI with DES implantation (n=300). VerifyNow P2Y12 assay vs. Light transmittance aggregometry (LTA) was evaluated on High post-treatment platelet reactivity (HPPR) on LTA (>50% aggregation induced by 5 μM ADP) (AUC 0.794, 95% CI 0.736-0.851, p=<0.001). A VerifyNow PRU value ≥ 239 optimally predicted high post-treatment platelet reactivity on LTA (AUC 0.794; 95% CI 0.736-0.851; P<0.001), with 83.6% sensitivity and 68.3% specificity.