Key result
Bleomycin-containing regimens in Indian patients with Hodgkin's lymphoma were associated with a 29% incidence of bleomycin pulmonary toxicity and a 5% mortality rate.
Why the study?
Bleomycin-containing regimens carry a risk of pulmonary toxicity, leading investigators to assess the genetic susceptibility among Indian Hodgkin lymphoma patients to bleomycin pulmonary toxicity.
What is the incidence of bleomycin pulmonary toxicity in Indian patients with Hodgkin's lymphoma?
Cohort (n=100)
No
What is the incidence of bleomycin pulmonary toxicity in Indian patients with Hodgkin's lymphoma?
The high incidence of bleomycin-induced pulmonary toxicity (29%) and associated mortality (5%) in Indian patients with Hodgkin's lymphoma highlights the need to explore alternative chemotherapy regimens without bleomycin.
High toxicity rates warrant vigilance in Indian Hodgkin lymphoma patients on bleomycin; leaves open whether bleomycin-free regimens improve safety.
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Prakashini Koteshwar (2019) conducted a cohort in Hodgkin's lymphoma (n=100). Bleomycin-containing regimen was evaluated on Bleomycin pulmonary toxicity (BPT). Bleomycin-containing regimens in Indian patients with Hodgkin's lymphoma were associated with a 29% incidence of bleomycin pulmonary toxicity and a 5% mortality rate.
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