Key result
R-propafenone prevents AF induction in Casq2-null mice by reducing spontaneous Ca elevations.
Why the study?
Does R-propafenone prevent atrial fibrillation in Casq2-null hearts?
Does R-propafenone prevent atrial fibrillation in Casq2-null hearts?
Inhibition of RyR2 Ca channels with R-propafenone prevents atrial fibrillation in Casq2-null hearts, highlighting a potential mechanism-based therapy for AF.
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R-propafenone may support RyR2-targeted AF prevention in models; leaves open translation to human therapy.
Faggioni et al. (2014) studied Atrial fibrillation. R-propafenone vs. S-enantiomer of propafenone was evaluated on Induction of atrial fibrillation and frequency/amplitude of spontaneous Ca elevations. R-propafenone significantly reduced the frequency and amplitude of spontaneous Ca elevations and prevented the induction of atrial fibrillation in Casq2-null mice.
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