What question did this study set out to answer?

To examine and compare the presence and distribution of CD4+ CD25+ Foxp3+ regulatory T cells in the lesional skin of patients with eczematous dermatitis, psoriasis vulgaris, and mycosis fungoides versus normal skin.

March 20, 2008British Journal of Dermatology

Profiles of Foxp3+ regulatory T cells in eczematous dermatitis, psoriasis vulgaris and mycosis fungoides

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Authors

TFTaku FujimuraTohoku University RORyuhei OkuyamaShinshu University YIYumiko ItoTohoku University

Discussion

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Implication

Immunohistological study uncovers distinct Foxp3+ regulatory T cell patterns across inflammatory skin lesions, suggesting localized immune deficits contribute to disease pathogenesis.

Key Points

To examine and compare the presence and distribution of CD4+ CD25+ Foxp3+ regulatory T cells in the lesional skin of patients with eczematous dermatitis, psoriasis vulgaris, and mycosis fungoides versus normal skin.
Analyzed fixed lesional skin sections via immunohistochemistry from 16 patients with psoriasis vulgaris, 17 with mycosis fungoides, and 18 with eczematous dermatitis, alongside 10 normal skin controls.
Quantified the proportion of epidermal and dermal CD3+, CD4+, and CD25+ cells expressing Foxp3.
Normal skin contained rare Foxp3+ cells, whereas psoriasis vulgaris, mycosis fungoides, and eczematous dermatitis tissues harbored substantial numbers of epidermal and dermal CD3+, CD4+, and CD25+ Foxp3+ regulatory T cells, with higher percentages in the epidermis than the dermis.
The percentage of Foxp3+ cells among CD3+ or CD4+ cells was significantly lower in eczematous dermatitis than in psoriasis vulgaris or mycosis fungoides.
The percentage of dermal Foxp3+ cells was significantly lower in psoriasis vulgaris than in eczematous dermatitis or mycosis fungoides.

Cite This Study

Fujimura et al. (2008) studied this question.

synapsesocial.com/papers/6aa4b8024ad6d94037dc39e6 https://doi.org/10.1111/j.1365-2133.2008.08504.x

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Implication

Immunohistological study uncovers distinct Foxp3+ regulatory T cell patterns across inflammatory skin lesions, suggesting localized immune deficits contribute to disease pathogenesis.

Profiles of Foxp3+ regulatory T cells in eczematous dermatitis, psoriasis vulgaris and mycosis fungoides

Discussion

Member takes

Implication

Key Points

Cite This Study

Profiles of Foxp3+ regulatory T cells in eczematous dermatitis, psoriasis vulgaris and mycosis fungoides

Discussion

Member takes

Implication

Key Points

Cite This Study

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