Key result
AMI mortality in working-age US adults fell ~51% overall despite transient COVID-19 disruption.
Why the study?
Contemporary trends in AMI-related mortality among young and middle-aged US individuals and the impact of the COVID-19 pandemic on these trends were unknown.
Observational (n=970,454)
Effect estimate: APC -2.92% (95% CI -3.22 to -2.75)
Absolute Event Rate: 15.29% vs 31.02%
AMI mortality in young and middle-aged US adults has steadily declined over the past 25 years, with a temporary spike during the COVID-19 pandemic, though demographic and regional disparities remain.
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Transient COVID disruption in AMI trends warrants monitoring; leaves open effects of disparities on sustained gains in younger adults.
Jabbar et al. (2025) conducted an observational in Acute myocardial infarction (AMI) (n=970,454). Calendar year (1999-2023) and COVID-19 pandemic was evaluated on Age-adjusted mortality rates (AAMRs) per 100,000 people (APC -2.92%, 95% CI -3.22 to -2.75). The COVID-19 pandemic transiently disrupted a 25-year decline in AMI-related mortality among US adults aged 25-64, which overall fell from 31.02 per 100,000 in 1999 to 15.29 in 2023.
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