Key result
Prostaglandin E2 alleviates diabetic coronary atherosclerosis by promoting M2 macrophage polarization via CREB/BDNF/TrkB signaling.
Why the study?
M2 macrophage polarization suppresses diabetic atherosclerosis and PGE2 is implicated in M2 development, but the specific mechanism in diabetic coronary atherosclerosis remained unknown.
Population
Clinical samples from DMAS patients, DMAS mice, and isolated macrophages
Comparison
Modification of BDNF and PGE2 levels vs controls
Design
Preclinical translational and animal experimental study
Authors
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Should not yet alter diabetic atherosclerosis management; leaves open human validation of PGE2-M2 polarization pathway.
Prostaglandin E2 alleviates diabetic coronary atherosclerosis by promoting M2 macrophage polarization through the activation of the CREB/BDNF/TrkB signaling pathway.
Bi et al. (2020) studied Diabetic coronary atherosclerosis. Prostaglandin E2 (PGE2) was evaluated on M2 macrophage polarization, atherosclerotic plaque, and lipid uptake. Prostaglandin E2 promotes M2 macrophage polarization by activating the CREB/BDNF/TrkB signaling pathway, thereby alleviating diabetic coronary atherosclerosis.
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