Excerpt Therapy has not previously altered the relentless progression of disseminated coccidioidomycosis. More than 50% mortality1 continues despite treatment with a variety of agents.2, 4 In the last year a new antibiotic, amphotericin B,† has been released to clinical investigators. In vitro studies3, 4 have shown good antifungal properties of this Streptomyces derivative. Encouraging results have been described in studies with animals.5, 6, 7, 8 Several reports4, 9-16 of effectiveness in disseminated coccidioidomycosis have recently appeared. The present paper describes a mycologic and clinical remission in a case of disseminated coccidioidomycosis produced by prolonged intravenous therapy with amphotericin B. CASE REPORT
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John A. Colwell (1959) studied this question.