What question did this study set out to answer?

To identify clinical and laboratory predictors of in-hospital mortality upon admission in hospitalized patients with HIV and disseminated histoplasmosis.

July 1, 2026The Brazilian Journal of Infectious DiseasesOpen Access

Predictors of mortality in hospitalized patients with disseminated histoplasmosis

View Full Paper

Ask AI

Bookmark

Authors

FGF GastaldiUniversidade Federal de Uberlândia FGFranciny M. GastaldiUniversidade Federal de Uberlândia FGFranciny M. GastaldiUniversidade Federal de Uberlândia

Discussion

Member takes

Implication

Retrospective cohort study reveals tachypnea predicts in-hospital mortality in patients with HIV and disseminated histoplasmosis, highlighting simple clinical markers for early triage.

Key Points

To identify clinical and laboratory predictors of in-hospital mortality upon admission in hospitalized patients with HIV and disseminated histoplasmosis.
Conducted a single-center retrospective cohort study of adult patients with HIV and disseminated histoplasmosis admitted to a Brazilian tertiary hospital between 2009 and 2023 (N=105).
Evaluated clinical and laboratory variables present at hospital admission using univariate and multivariate logistic regression models with in-hospital mortality as the primary outcome.
The overall in-hospital mortality rate was 28.5% (30/105 deaths), with elevated baseline urea, ferritin, and lactate dehydrogenase (LDH) levels associated with mortality in univariate analysis.
Multivariate analysis identified tachypnea at admission as an independent predictor of in-hospital mortality (OR = 3.9; 95% CI 1.39–10.97; p < 0.001).
Dysphagia was independently associated with reduced in-hospital mortality (OR = 0.18; 95% CI 0.03–0.98; p = 0.047).

Cite This Study

Gastaldi et al. (2026) studied this question.

synapsesocial.com/papers/6aa4bac4f188d5f0710a49b7 https://doi.org/10.1016/j.bjid.2026.105891

View Full Paper

Ask AI

Bookmark

July 1, 2026The Brazilian Journal of Infectious DiseasesOpen Access

Predictors of mortality in hospitalized patients with disseminated histoplasmosis

View Full Paper

Ask AI

Bookmark

Authors

FGF GastaldiUniversidade Federal de Uberlândia FGFranciny M. GastaldiUniversidade Federal de Uberlândia FGFranciny M. GastaldiUniversidade Federal de Uberlândia

Discussion

Member takes

Implication

Retrospective cohort study reveals tachypnea predicts in-hospital mortality in patients with HIV and disseminated histoplasmosis, highlighting simple clinical markers for early triage.

Key Points

To identify clinical and laboratory predictors of in-hospital mortality upon admission in hospitalized patients with HIV and disseminated histoplasmosis.
Conducted a single-center retrospective cohort study of adult patients with HIV and disseminated histoplasmosis admitted to a Brazilian tertiary hospital between 2009 and 2023 (N=105).
Evaluated clinical and laboratory variables present at hospital admission using univariate and multivariate logistic regression models with in-hospital mortality as the primary outcome.
The overall in-hospital mortality rate was 28.5% (30/105 deaths), with elevated baseline urea, ferritin, and lactate dehydrogenase (LDH) levels associated with mortality in univariate analysis.
Multivariate analysis identified tachypnea at admission as an independent predictor of in-hospital mortality (OR = 3.9; 95% CI 1.39–10.97; p < 0.001).
Dysphagia was independently associated with reduced in-hospital mortality (OR = 0.18; 95% CI 0.03–0.98; p = 0.047).

Cite This Study

Gastaldi et al. (2026) studied this question.

synapsesocial.com/papers/6aa4bac4f188d5f0710a49b7 https://doi.org/10.1016/j.bjid.2026.105891

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark