Key result
Amlodipine and 5-methylurapidil suppress induced renal vasoconstriction by up to ~59% in rats.
Population
Pentobarbital anaesthetised normotensive rats and stroke-prone spontaneously hypertensive rats (SPSHR)
Design
Preclinical
Authors
Loading...
Does not support clinical use of subtype-selective agents; leaves open α1A-receptor targeting in human hypertension.
p-value: p=< 0.05–0.001
Renal postjunctional α1-adrenoceptors mediating vasoconstriction in both normotensive and stroke-prone spontaneously hypertensive rats exhibit characteristics of the α1a-adrenoceptor subtype, requiring extracellular calcium.
Sattar et al. (1994) studied Normotension and stroke-prone spontaneously hypertensive rats. Amlodipine, 5-methylurapidil, and chloroethylclonidine was evaluated on Renal vasoconstrictor responses to renal nerve stimulation, phenylephrine, and methoxamine (p=< 0.05–0.001). Amlodipine and 5-methylurapidil suppressed renal nerve-, phenylephrine-, and methoxamine-induced vasoconstrictions by 21-59% (p<0.05-0.001) in normotensive and hypertensive rats.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: