Key result
MTHFR and PAI-1 mutations affect up to ~64% of Mexican women, far exceeding FVL and PT.
Why the study?
The study was conducted to report the incidence of thrombophilias and their importance in the development of thrombotic events in Mexican women.
Cross-Sectional (n=184)
No
p-value: p=<0.05
There is a high incidence of MTHFR-C677T and PAI-1 4G/5G mutations in Mexican women of reproductive age, potentially increasing susceptibility to thrombotic events.
May support ethnicity-specific thrombophilia panels in reproductive-age Mexican women; leaves open causal thrombotic risk pending prospective studies.
Objective: To report the incidence of thrombophilias and importance in the development of thrombotic events in a population of Mexican women. Methods: Is a retrospective, observational and cross-sectional study of 184 women of reproductive age, where the age, weight, height and study of hereditary thrombophilias of FVL-G1691A, PT-G20210A, MTHFR-C677T and PAI-1 4G/5G were studied. Four groups were formed: 1) FVL-G1691A, 2) PT-G20210A, 3) MTHFR-C677T and 4) PAI-1 4G/5G, each group was separated by homozygous and heterozygous mutation. Results: MTHFR-C677T and PAI-1 4G/5G present higher incidence (48.9 and 64%), when comparing with FVL-G1691A and PT-G20210A (3.8 and 0.5%) (p<0.05), higher incidence of PAI-1 4G/5G was observed, when compared to MTHFR-C677T (64.6 vs. 48.9%, p<0.05), difference that was not observed when comparing FVL-G1691A with PT-G20210A (3.8 vs. 0.5%, p>0.05). When patients presented only one thrombophilia, the highest incidence is of MTHFR-C677T and PAI-1 4G>5G (16.5 and 35.2%). Patients with multiple thrombophilias had an incidence of MTHFR-C677T with PAI-1 4G/5G of 30.2%. Conclusion: Our results in the population of Mexican women, we report a high incidence of the MTHFR-C677T and PAI-1 4G / 5G mutation, which makes them susceptible to the development of thrombotic events.
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Manuel et al. (2020) conducted a cross-sectional in Hereditary thrombophilias (n=184). Hereditary thrombophilias (MTHFR-C677T, PAI-1 4G/5G, FVL-G1691A, PT-G20210A) was evaluated on Incidence of hereditary thrombophilias (p=<0.05). In a population of 184 Mexican women, the incidence of MTHFR-C677T and PAI-1 4G/5G mutations was 48.9% and 64%, respectively, which was significantly higher than FVL-G1691A (3.8%) and PT-G20210A (0.5%).
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