What question did this study set out to answer?

To establish minimum inhibitory concentration (MIC) and zone diameter distributions and define EUCAST epidemiological cut-off (ECOFF) values for Burkholderia pseudomallei using standardized methodology.

July 9, 2020Clinical Microbiology and InfectionOpen Access

Burkholderia pseudomallei multi-centre study to establish EUCAST MIC and zone diameter distributions and epidemiological cut-off values

View Full Paper

Ask AI

Bookmark

Authors

OKOnur KaratunaVäxjö Kommun DDDavid A. B. DanceUniversity of London EMErika MatuschekEuclid University

Discussion

Member takes

Implication

Multicenter study demonstrates EUCAST epidemiological cut-offs across eight antimicrobials in Burkholderia pseudomallei, highlighting standardized benchmarks to set clinical breakpoints.

Key Points

To establish minimum inhibitory concentration (MIC) and zone diameter distributions and define EUCAST epidemiological cut-off (ECOFF) values for Burkholderia pseudomallei using standardized methodology.
Tested 361 non-consecutive, non-duplicate clinical B. pseudomallei isolates (9–70 per centre) across eight study centres, intentionally including isolates with and without suspected resistance mechanisms.
Performed antimicrobial susceptibility testing against eight antimicrobials using broth microdilution (BMD) and the EUCAST disc diffusion method under EUCAST Development Laboratory quality assurance.
Generated MIC and disc diffusion zone diameter distribution profiles across all 361 clinical B. pseudomallei isolates for eight antimicrobials.
Established MIC and zone diameter ECOFFs (mg/L; mm) for amoxicillin-clavulanic acid (8; 22), ceftazidime (8; 22), imipenem (2; 29), meropenem (2; 26), doxycycline (2; none), tetracycline (8; 23), chloramphenicol (8; 22), and trimethoprim-sulfamethoxazole (4; 28).

Cite This Study

Karatuna et al. (2020) studied this question.

synapsesocial.com/papers/6aa4c2d572bda1c777aa2053 https://doi.org/10.1016/j.cmi.2020.07.001

View Full Paper

Ask AI

Bookmark

Implication

Multicenter study demonstrates EUCAST epidemiological cut-offs across eight antimicrobials in Burkholderia pseudomallei, highlighting standardized benchmarks to set clinical breakpoints.

Burkholderia pseudomallei multi-centre study to establish EUCAST MIC and zone diameter distributions and epidemiological cut-off values

Discussion

Member takes

Implication

Key Points

Cite This Study

Burkholderia pseudomallei multi-centre study to establish EUCAST MIC and zone diameter distributions and epidemiological cut-off values

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider