Models of host-parasite interaction and MHC polymorphism.

Models of Host-Parasite Interaction and MHC PolymorphismIn arguing that natural selection at major histocompatibility complex (MHC) loci is frequency-dependent rather than overdominant, SLADE and MCCALLUM rely heavily on previously published theoretical models of host-parasite interactions.While such models can yield valuable insights, it is important to recall that they are based on assumptions which are not necessarily justified for real host-parasite interactions.Here we point out several assumptions crucial