Key result
Periostin drives dental connective tissue development and maintenance by mediating collagen fibrillogenesis and mechanical stress.
This review highlights the integral role of periostin in the development, maintenance, and repair of dental connective tissues.
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May inform dental regenerative strategies; leaves open periostin’s translational relevance to cardiac matrix remodeling.
The matricellular protein periostin is strongly expressed in collagen-rich connective tissues such as periodontal ligaments (PDLs), skeletal muscle, adipose tissue, tendons, skin, and bone. It is prominent in tumorigenesis, angiogenesis, and cardiac repair. It is localized in the periosteum and PDL, where it is seen in the cytoplasmic extensions of the PDL fibroblasts. It plays a key role in morphogenesis, postnatal development, and maintenance of the tooth, and related structures. It mediates and augments collagen fibrillogenesis, cell migration, adhesion, response to mechanical stress, and wound healing. It has been shown to be an integral regulator of periodontal disease pathogenesis and repair. This review focuses on the various functional aspects of periostin in dental connective tissue development and maintenance.
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Romanos et al. (2013) conducted a review in Dental connective tissue development and maintenance. Periostin was evaluated. Periostin plays a key role in the morphogenesis, postnatal development, and maintenance of dental connective tissues, mediating collagen fibrillogenesis and response to mechanical stress.
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