Key result
High OSA risk predicts ~353% higher odds of procedural failure after AF ablation.
Why the study?
Does high risk of obstructive sleep apnoea assessed by the Berlin Questionnaire predict procedural failure after catheter ablation of atrial fibrillation?
Cohort (n=210)
Does high risk of obstructive sleep apnoea assessed by the Berlin Questionnaire predict procedural failure after catheter ablation of atrial fibrillation?
Odds Ratio: 4.53 (95% CI 1.21–16.87)
Absolute Event Rate: 30.4% vs 14.4%
p-value: p=0.02
High risk of obstructive sleep apnea identified by the simple Berlin Questionnaire strongly predicts procedural failure after atrial fibrillation ablation.
May support OSA risk assessment before AF ablation; leaves open whether treatment improves outcomes.
AIMS: Obstructive sleep apnoea (OSA) is a risk factor for atrial fibrillation (AF) recurrence after catheter ablation. The purpose of this study is to determine whether OSA assessed by the simple tool, the Berlin Questionnaire (BQ), is useful in predicting the efficacy of catheter ablation of AF. METHODS AND RESULTS: The patient population consisted of 210 consecutive patients [mean age 58 +/- 10 years, 167 (80%) male, 119 (57%) paroxysmal] who underwent catheter ablation of AF and completed the BQ. Clinical success was defined as at least 90% reduction in AF burden after 3-month blanking period. Mean duration of follow-up was 25 +/- 12 months. One hundred and one of the 118 (85%) patients at low risk for OSA had clinical success as opposed to 64 of the 92 (70%) patients at high risk for OSA on BQ (P = 0.005). On multivariate analysis, only high-risk for OSA on BQ emerged as an independent predictor of procedural failure (OR 4.53, CI: 1.21-16.87, P = 0.02). CONCLUSION: High risk of OSA on BQ predicts procedural failure after catheter ablation of AF. We recommend the use of BQ for risk-stratifying patients for OSA prior to AF ablation procedures and to identify patients for formal sleep study assessment.
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Chilukuri et al. (2009) conducted a cohort in Atrial fibrillation (n=210). High risk for obstructive sleep apnoea on the Berlin Questionnaire vs. Low risk for obstructive sleep apnoea on the Berlin Questionnaire was evaluated on Procedural failure (failure to achieve at least 90% reduction in AF burden after 3-month blanking period) (OR 4.53, 95% CI 1.21-16.87, p=0.02). High risk of obstructive sleep apnea on the Berlin Questionnaire independently predicted procedural failure after catheter ablation of atrial fibrillation (OR 4.53; 95% CI 1.21-16.87; P=0.02).
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