Key result
Transcatheter tricuspid-valve replacement plus medical therapy was superior to medical therapy alone, though the most objective marker of improvement was a modest 30 m increase in 6-minute walk distance.
Why the study?
Does transcatheter tricuspid-valve replacement plus medical therapy improve outcomes compared to medical therapy alone in patients with severe tricuspid regurgitation?
Does transcatheter tricuspid-valve replacement plus medical therapy improve outcomes compared to medical therapy alone in patients with severe tricuspid regurgitation?
Answers are grounded in this paper and cite their sources.
This letter critiques the TRISCEND II trial, highlighting that the primary composite endpoint's success was largely driven by subjective measures susceptible to placebo effects, with only a modest 30 m improvement in 6-minute walk distance.
To the Editor: In the TRISCEND II trial, Hahn and colleagues (Jan. 9 issue) 1 concluded that transcatheter tricuspid-valve replacement plus medical therapy was superior to medical therapy alone. The primary outcome was a hierarchical composite end point that was analyzed with the use of a win ratio. The outcome was focused on wins that were based on soft end points, such as New York Heart Association class and quality-of-life questionnaires, which are heavily influenced by the placebo effect. The most objective marker of clinical improvement was a modest increase of 30 m in the 6-minute walk distance, which was reported . . .
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A 2025 study conducted a letter in Severe Tricuspid Regurgitation. Transcatheter tricuspid-valve replacement plus medical therapy vs. Medical therapy alone was evaluated on Hierarchical composite end point analyzed with the use of a win ratio. Transcatheter tricuspid-valve replacement plus medical therapy was superior to medical therapy alone, though the most objective marker of improvement was a modest 30 m increase in 6-minute walk distance.
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