Review demonstrates multifunctional self-healing polymers in chronic and infected wounds, highlighting their capacity to integrate autonomous repair with targeted therapeutic delivery.
Self‐healing polymers have emerged as advanced biomaterials for wound‐healing and wound‐dressing applications due to their ability to autonomously restore structural integrity and maintain therapeutic performance under dynamic conditions. By mimicking biological repair mechanisms, these materials address key limitations of conventional wound dressings, including mechanical failure, infection susceptibility and poor adaptability to complex wound environments. This review critically examines recent progress in self‐healing polymeric systems, with a focus on intrinsic and extrinsic healing mechanisms, material design strategies and multifunctional performance in cutaneous, bacteria‐infected and diabetic wounds. Representative case studies are discussed to highlight how dynamic polymer networks can integrate self‐repair, antimicrobial activity, angiogenic stimulation and controlled drug delivery. Current challenges, including mechanical–biological trade‐offs, translational barriers and long‐term stability, are analyzed, and future directions toward intelligent, sustainable and clinically relevant self‐healing wound dressings are outlined.
No takes yet. Share an insight, caveat, or question.
Moshiri et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: