Key result
Echo abnormalities linked to higher 1-year exacerbation or death rates in COPD.
Why the study?
Cardiac disorders are common in COPD and worsen outcomes, but the prognostic significance of echocardiographic parameters on exacerbation rates and mortality required assessment.
Do echocardiographic abnormalities predict moderate and severe exacerbations and death in patients with COPD?
Population
96 patients with COPD without exacerbation in the previous 1 month
Comparison
Prognostic value of echocardiographic parameters
Design
Prospective study
Follow-up
1 year
Authors
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Echocardiographic abnormalities may flag higher 1-year risk in COPD; hypothesis-generating and requires prospective validation before practice change.
Observational (n=96)
No
Do echocardiographic abnormalities predict moderate and severe exacerbations and death in patients with COPD?
Absolute Event Rate: 86.2% vs 58.2%
p-value: p=0.0055
Echocardiographic abnormalities, specifically deceleration time deviations and increased septal thickness, are associated with a higher risk of exacerbations and mortality in patients with COPD.
Mekov et al. (2022) conducted an observational in Chronic Obstructive Pulmonary Disease (COPD) (n=96). Abnormal deceleration time (echocardiographic deviation) vs. Normal deceleration time was evaluated on Composite of time to the first moderate or severe exacerbation or death (p=0.0055). Echocardiographic abnormalities, specifically deceleration time deviations (86.2% vs 58.2%) and increased septal thickness (55.6% vs 24.6%), were associated with a significantly higher rate of exacerbations or death at 1 year in patients with COPD.
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