The Pt(II) complexes of 1,3-diphenylpropane-1,3-diamines (part IV2)) were tested for DNA interaction (UV-difference spectroscopy, Tables 1 and 2), for affinity to the estrogen receptor (calf uterus cytosol; scarcely any affinity), and for cytostatic activity at estrogen independent MDA-MB 231 cells (Tables 3 and 4) and estrogen dependent MCF-7 cells (Tables 5 and 6). The data are compared with those reported for the analogous 1,2-diphenylethane-1,2-diamine-Pt(II) complexes: most probably, the cytostatic activity is not mediated by the estrogen receptor.
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Kammermeier et al. (1995) studied this question.
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