Key result
Ex vivo 810 nm diode laser causes localized thermal damage in ~8% of human aortic tissue.
Why the study?
To assess whether 810 nm diode laser operative conditions ensuring endograft fabric fenestration are harmless to surrounding biological tissue.
Does 810 nm diode laser irradiation cause thermal damage to human aortic tissue during in situ fenestration?
Does 810 nm diode laser irradiation cause thermal damage to human aortic tissue during in situ fenestration?
Ex vivo evaluation suggests that 810 nm diode laser fenestration can be safely used for endovascular treatment without causing widespread thermal damage to surrounding aortic tissue.
May enable precise laser fenestration in short-neck aneurysms; hypothesis-generating ex vivo data leave clinical adoption open pending in vivo trials.
The in situ laser fenestration is an interesting option for the endovascular treatment of short-necked aneurysms with an intraoperative modification of a standard endograft. According to literature evidence, diode laser emitting in the near-infrared wavelength (810 nm) can be successfully used to fenestrate the endograft fabric. This paper describes a three-dimensional navigation system for the accurate targeting of the fenestration site, then reports results of an ex vivo study to assess whether the laser operative conditions, which ensure the fabric fenestration, are harmless for the biological tissue surrounding the endoprosthesis. Two hundred twenty-five samples of human aorta, including healthy specimens and abdominal aortic aneurysm samples, were irradiated ex vivo using a 810 nm diode laser. Energy and pulse duration were varied. Irradiated tissues were fixed in formaldehyde, sectioned and subjected to histological examination. Only 7.5% of the irradiated samples exhibited a thermal damage, which was always confined to the contact point between the laser fiber tip and the aortic wall. These experiments suggest that the diode laser can be safely used for the proposed surgical application.
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Piazza et al. (2019) studied Abdominal aortic aneurysm (n=225). 810 nm diode laser was evaluated on Thermal damage. Ex vivo irradiation of human aortic tissue using an 810 nm diode laser caused thermal damage in only 7.5% of samples, confined to the contact point.
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