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The histamine H 2 -receptor antagonists cimetidine and oxmetidine were administered in a dose of 1 g/day for 4 weeks to fifteen duodenal ulcer patients. Their effects on the parietal cell population, the intracellular mucosal glycoproteins and the surface gastric epithelium were investigated by comparing pre- and post-treatment fundic biopsies. It was found that treatment with either agent had no effect on any of the assessments made.
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Emmanouilidis et al. (1982) studied this question.
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