Key result
Nonpulsatile circulation during TLHB increases and transforms rabbit aortic depressor nerve activity into continuous discharge.
Why the study?
Does nonpulsatile systemic circulation during total left heart bypass alter arterial baroreceptor reflex activity in rabbits?
Does nonpulsatile systemic circulation during total left heart bypass alter arterial baroreceptor reflex activity in rabbits?
Nonpulsatile systemic circulation acutely alters afferent arterial baroreceptor reflex activity without significantly changing efferent renal sympathetic nerve activity in a rabbit model.
Nonpulsatile flow may alter baroreflex afferents in rabbits; leaves open relevance to human continuous-flow support.
We studied the changes in arterial baroreceptor reflex (ABR) afferent activity and efferent activity induced by nonpulsatile systemic circulation (NC) during total left heart bypass (TLHB) in rabbits. To evaluate the influence of the circuit priming fluid and exposure to NC, we directly measured aortic depressor nerve activity (ADNA) (n = 5) and renal sympathetic nerve activity (RSNA) (n = 5) before the start of partial left heart bypass (PLHB) (Before), after PHLB (After), and 5 min after the start of TLHB (During THLB) while maintaining the mean aortic pressure. The circuit priming fluid did not affect the ABR. ADNA exhibited periodic discharge at Before and After, but at During THLB, this periodic discharge transformed into a continuous discharge, and ADNA increased significantly. However, there were no significant differences in RSNA. Our results suggested that in the acute phase under NC, the ABR differed from that under natural circulation.
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Shomura et al. (1999) studied Rabbits undergoing total left heart bypass (n=10). Nonpulsatile systemic circulation during total left heart bypass vs. Before and after partial left heart bypass was evaluated on Aortic depressor nerve activity (ADNA) and renal sympathetic nerve activity (RSNA). Nonpulsatile systemic circulation during total left heart bypass in rabbits significantly increased aortic depressor nerve activity and transformed it into a continuous discharge.
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