Key result
Nonpulsatile left heart bypass did not significantly alter renal sympathetic nerve activity or heart rate in anaesthetized rabbits, either before or after bilateral vagotomy.
Why the study?
Does nonpulsatile left heart bypass alter renal sympathetic nerve activity in anaesthetized rabbits?
Does nonpulsatile left heart bypass alter renal sympathetic nerve activity in anaesthetized rabbits?
Nonpulsatile left heart bypass does not alter renal sympathetic nerve activity in a rabbit model, clarifying baroreflex control during this type of mechanical support.
Supports baroreflex investigation during nonpulsatile support; leaves open translation to human mechanical circulatory support.
To determine the effects of nonpulsatile left heart bypass (LHB) on sympathetic nerve activity the renal sympathetic nerve activity (RSNA) was directly measured in rabbits. In anaesthetized rabbits (n=6), LHB was instituted with a centrifugal pump. Before and during LHB, heart rate (HR), arterial pressure (AP), central venous pressure (CVP), left atrial pressure (LAP) and spike counts of RSNA were measured. After bilateral vagotomy (section of the afferent inputs of the cardiac reflex arc) the same parameters were measured before and during LHB. Data were obtained at the same level of mean AP before and during LHB. Mean AP and CVP were not changed by LHB before and after vagotomy. LAP was significantly decreased by LHB before and after vagotomy. RSNA and HR were not significantly changed by LHB before and after vagotomy. Our results clarify the complex baroreflex control during nonpulsatile LHB and indicate that RSNA is not altered by LHB.
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Tokunaga et al. (2000) studied this question. Nonpulsatile left heart bypass (LHB) vs. Baseline (before LHB) was evaluated on Renal sympathetic nerve activity (RSNA). Nonpulsatile left heart bypass did not significantly alter renal sympathetic nerve activity or heart rate in anaesthetized rabbits, either before or after bilateral vagotomy.
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