Key result
Acute L-NAME administration caused a significantly greater decrease in renal sympathetic nerve activity (68% of control) compared to lumbar sympathetic nerve activity (84% of control) in conscious rabbits.
Why the study?
Do acute stimuli like L-NAME, volume expansion, and hypoxia differentially regulate renal and lumbar sympathetic nerve activity in conscious rabbits?
Do acute stimuli like L-NAME, volume expansion, and hypoxia differentially regulate renal and lumbar sympathetic nerve activity in conscious rabbits?
Absolute Event Rate: 68% vs 84%
This preclinical study demonstrates that renal and lumbar sympathetic nerve activities are differentially controlled in response to specific acute stimuli such as nitric oxide synthase inhibition and volume expansion.
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Regional sympathetic differences with NOS inhibition in rabbits; hypothesis-generating for human autonomic regulation and requires clinical validation.
Ramchandra et al. (2005) studied this question. Acute stimuli (L-NAME, volume expansion, hypoxia) vs. Baseline/control values was evaluated on Change in renal sympathetic nerve activity (RSNA) vs lumbar sympathetic nerve activity (LSNA). Acute L-NAME administration caused a significantly greater decrease in renal sympathetic nerve activity (68% of control) compared to lumbar sympathetic nerve activity (84% of control) in conscious rabbits.
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