Key result
Sinoaortic deafferentation in rats increased mean arterial pressure lability without being driven by sympathetic discharge variations, and rostral medulla blockade reduced RSNA to 40% of control.
Population
Conscious unrestrained rats and anesthetized rats
Comparison
Sino-aortic deafferentation and bilateral… vs Sham operation
Design
Preclinical
Follow-up
1 day and 14 days
Authors
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Questions sympathetic mediation of pressure lability in rats; leaves open non-vasomotor RSNA roles for human hypertension research.
In experimental rat models, arterial pressure lability following sinoaortic deafferentation does not appear to be driven by variations in sympathetic discharge, and a substantial fraction of renal sympathetic nerve activity may be non-vasomotor.
Barrès et al. (1989) studied Experimental hypertension. Sinoaortic deafferentation (SAD) and lidocaine microinjections vs. Sham operation / control was evaluated on Renal sympathetic nerve activity (RSNA), heart rate (HR), and mean arterial pressure (MAP) lability and correlation. Sinoaortic deafferentation in rats increased mean arterial pressure lability without being driven by sympathetic discharge variations, and rostral medulla blockade reduced RSNA to 40% of control.
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