Key result
Surgical reversal of renovascular hypertension in rats reduced blood pressure, accompanied by decreases in heart rate (-26 ± 15 beats/min, P<0.05) and sympathetic nerve activity.
Population
27 rats with two-kidney, one-clip renovascular hypertension
Comparison
Surgical removal of the renal artery clip with… vs Lowering blood pressure with nitroprusside to…
Design
Preclinical
Follow-up
90 minutes
Authors
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No immediate clinical implications from this rat model; leaves open vagal afferent roles in human baroreflex modulation after hypertension reversal.
p-value: p=< 0.05
Surgical reversal of renovascular hypertension in rats suppresses the expected baroreceptor reflex, partly mediated by cardiopulmonary vagal afferents.
Göthberg et al. (1986) studied Two-kidney, one-clip renovascular hypertension (n=27). Surgical reversal of renovascular hypertension (declipping) vs. Nitroprusside-induced hypotension was evaluated on Changes in efferent renal sympathetic nerve activity (RSNA) and heart rate (HR) (p=< 0.05). Surgical reversal of renovascular hypertension in rats reduced blood pressure, accompanied by decreases in heart rate (-26 ± 15 beats/min, P<0.05) and sympathetic nerve activity.
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