Why the study?
Does surgical or pharmacological reduction of blood pressure improve baroreflex sensitivity in two-kidney, one-clip hypertensive rats?
Population
Conscious early phase (<6 weeks) two-kidney, one-clip hypertensive rats
Comparison
Surgical reversal of hypertension by removal of… vs Normotensive sham-clipped rats
Design
Preclinical
Follow-up
Up to 3 weeks
Authors
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May warrant caution with early interventions after acute BP lowering in hypertension; leaves open translation of baroreflex recovery timelines from this rat model to humans.
Does surgical or pharmacological reduction of blood pressure improve baroreflex sensitivity in two-kidney, one-clip hypertensive rats?
In a rat model of renovascular hypertension, baroreflex sensitivity remains impaired 24 hours after blood pressure reduction but improves by 3 weeks.
Edmunds et al. (1990) studied this question.
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