Why the study?
Does the reversal of Goldblatt two-kidney one-clip hypertension improve baroreceptor reflex sensitivity in male Wistar rats?
Population
Male Wistar rats with Goldblatt two-kidney one-clip hypertension
Comparison
Removal of a left renal artery clip of 0.18 mm… vs Normotensive rats of comparable ages
Design
Preclinical
Follow-up
1, 3, 7, 14 and 25 days
Authors
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Rapid baroreflex recovery after hypertension reversal in rats; leaves open functional mechanisms beyond structural adaptation and clinical translation.
Does the reversal of Goldblatt two-kidney one-clip hypertension improve baroreceptor reflex sensitivity in male Wistar rats?
Baroreflex sensitivity is restored early upon reversal of renovascular hypertension in a rat model, suggesting mechanisms beyond structural vascular adaptation.
Jones et al. (1982) studied this question.
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