Why the study?
Does the development of renovascular hypertension reduce baroreflex sensitivity in male Wistar rats?
Population
Male Wistar rats in which the left renal arteries were constricted by silver wire clips of 0.18 mm internal…
Comparison
Induction of renovascular hypertension vs Normal control rats of comparable ages
Design
Preclinical
Follow-up
Up to 25 days
Authors
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Does not guide clinical hypertension management; extends preclinical evidence that baroreflex impairment precedes hypertrophy in renovascular models.
Does the development of renovascular hypertension reduce baroreflex sensitivity in male Wistar rats?
Baroreflex sensitivity decreases early in the development of renovascular hypertension, preceding structural vascular adaptation and left ventricular hypertrophy.
Jones et al. (1980) studied this question.
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