Key result
In a rat model of renovascular hypertension, animals with greater initial arterial baroreflex sensitivity developed significantly lower systolic blood pressure after renal artery clipping.
Why the study?
Does arterial baroreceptor reflex counteract long-term blood pressure increase in a rat model of renovascular hypertension?
Does arterial baroreceptor reflex counteract long-term blood pressure increase in a rat model of renovascular hypertension?
Arterial baroreflex sensitivity inversely correlates with the severity of renovascular hypertension in rats, suggesting it plays a role in long-term blood pressure regulation.
Answers are grounded in this paper and cite their sources.
No immediate clinical implications for hypertension; hypothesis-generating for baroreflex sensitivity in long-term BP regulation.
INTRODUCTION: The present study tested the hypothesis that long-term effects of baroreceptor activation might contribute to the prevention of persistent arterial blood pressure (BP) increase in the rat model of renovascular hypertension (HTN). METHODS: Repetitive arterial baroreflex (BR) testing was performed in normo- and hypertensive rats. The relationship between initial arterial BR sensitivity and severity of subsequently induced two-kidney one-clip (2K1C) renovascular HTN was studied in Wistar rats. Additionally, the time course of changes in systolic BP (SBP) and cardiac beat-to-beat (RR) interval was studied for 8 weeks after the induction of 2K1C renovascular HTN in the rats with and without sinoaortic denervation (SAD). In a separate experimental series, cervical sympathetic nerve activity (cSNA) was assessed in controls, 2K1C rats, WKY rats, and SHR. RESULTS: The inverse correlation between arterial BR sensitivity and BP was observed in the hypertensive rats during repetitive arterial BR testing. The animals with greater initial arterial BR sensitivity developed lower BP values after renal artery clipping than those with lower initial arterial BR sensitivity. BP elevation during the first 8 weeks of renal artery clipping in 2K1C rats was associated with decreased sensitivity of arterial BR. Although SAD itself resulted only in greater BP variability but not in persistent BP rise, the subsequent renal artery clipping invariably resulted in the development of sustained HTN. The time to onset of HTN was found to be shorter in the rats with SAD than in those with intact baroreceptors. cSNA was significantly greater in the 2K1C rats than in controls. CONCLUSIONS: Arterial BR appears to be an important mechanism of long-term regulation of BP, and is believed to be involved in the prevention of BP rise in the rat model of renovascular HTN.
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Tsyrlin et al. (2013) studied Renovascular Hypertension (n=135). High initial arterial baroreflex sensitivity (>1.2 ms/mm Hg) vs. Low initial arterial baroreflex sensitivity (<1.2 ms/mm Hg) was evaluated on Systolic blood pressure at 8 weeks after renal artery clipping (mm Hg) (p=<0.05). In a rat model of renovascular hypertension, animals with greater initial arterial baroreflex sensitivity developed significantly lower systolic blood pressure after renal artery clipping.
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