Key result
Prolonged nonpulsatile left heart bypass significantly diminished vascular constrictive function, with deltaSVR decreasing from 1,239 at baseline to 746 dyne x s x cm(-5) at 4 weeks.
Why the study?
Does prolonged nonpulsatile left heart bypass diminish vasoconstrictive function compared to pulsatile bypass in adult goats?
Population
3 adult goats
Comparison
Nonpulsatile left heart bypass (NPLHB) for 4 weeks vs Pulsatile left heart bypass for 2 weeks
Design
Preclinical
Follow-up
6 weeks (2 weeks PLHB followed by 4 weeks NPLHB)
Authors
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Nonpulsatile bypass may impair vasoconstriction in goats; leaves open whether pulsatile flow matters for human LVADs.
Does prolonged nonpulsatile left heart bypass diminish vasoconstrictive function compared to pulsatile bypass in adult goats?
Absolute Event Rate: 746% vs 1239%
Prolonged nonpulsatile left heart bypass significantly diminishes the constrictive function of the vascular system in an animal model.
Nishimura et al. (1999) studied this question. Nonpulsatile left heart bypass (NPLHB) vs. Pulsatile left heart bypass (PLHB) was evaluated on Elevation of systemic vascular resistance (deltaSVR) after norepinephrine injection. Prolonged nonpulsatile left heart bypass significantly diminished vascular constrictive function, with deltaSVR decreasing from 1,239 at baseline to 746 dyne x s x cm(-5) at 4 weeks.
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