Why the study?
Does long-term nonpulsatile left heart bypass alter the mechanical properties and structure of the aortic wall in adult goats?
Population
15 adult goats (53-68 kg)
Comparison
Long-term nonpulsatile left heart bypass for 31… vs Pulsatile LHB for 24 to 130 days and normal…
Design
Preclinical
Follow-up
31 to 381 days
Authors
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Nonpulsatile LHB induces aortic thinning and elastin remodeling in goats without stiffness change; leaves open relevance to human LVAD support.
Does long-term nonpulsatile left heart bypass alter the mechanical properties and structure of the aortic wall in adult goats?
Long-term nonpulsatile left heart bypass in a goat model induces significant structural thinning and elastin changes in the aortic wall without significantly altering its mechanical stiffness.
Nishimura et al. (1999) studied this question.
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