May 1, 1998Artificial Organs

Prolonged Nonpulsatile Left Heart Bypass with Reduced Systemic Pulse Pressure Causes Morphological Changes in the Aortic Wall

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Why the study?

Does prolonged nonpulsatile left heart bypass cause morphological changes in the aorta in adult goats?

Population

19 adult goats

Comparison

Prolonged nonpulsatile left heart bypass (LHB) vs Pulsatile LHB and normal control

Design

Preclinical

Authors

TNTakashi NishimuraNational Cerebral and Cardiovascular Center ETEisuke TatsumiNational Cerebral and Cardiovascular Center STShigeko TakaichiMayo Clinic

Discussion

Member takes

Implication

May warrant aortic monitoring in nonpulsatile support; leaves open human translation from this goat model.

Structured PICO

Does prolonged nonpulsatile left heart bypass cause morphological changes in the aorta in adult goats?

Population

19 adult goats

Intervention

Prolonged nonpulsatile left heart bypass (LHB)

Comparator

Pulsatile LHB and normal control

Outcome

Morphological changes in the descending aorta (wall thickness, volume ratio of smooth muscle cells, SMC type classification, cell density)surrogate

Prolonged nonpulsatile left heart bypass causes morphological atrophic changes in the aorta, including wall thinning and altered smooth muscle cell characteristics.

Cite This Study

Nishimura et al. (1998) studied this question.

synapsesocial.com/papers/6a70ff53e36a167817e2d3cf https://doi.org/10.1046/j.1525-1594.1998.06137.x

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Bookmark

Prolonged Nonpulsatile Left Heart Bypass with Reduced Systemic Pulse Pressure Causes Morphological Changes in the Aortic Wall

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Prolonged Nonpulsatile Left Heart Bypass with Reduced Systemic Pulse Pressure Causes Morphological Changes in the Aortic Wall

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider