Key result
Prolonged continuous flow left heart bypass in goats significantly increased the percentage of proliferating cells in the juxtaglomerular areas compared to healthy controls (9.9% vs 4.6%, p=0.025).
Why the study?
Does prolonged continuous flow left heart bypass cause morphological changes in the renal arterial systems in a goat model?
Does prolonged continuous flow left heart bypass cause morphological changes in the renal arterial systems in a goat model?
Prolonged continuous flow left heart bypass causes proliferation of smooth muscle cells in the afferent arterioles and perivascular tissue of the kidney in a goat model.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for continuous-flow effects on renal arterioles; should not change LVAD practice pending human data.
We investigated morphological changes of the arterial systems in the kidneys under prolonged continuous flow left heart bypass. Twelve goats were subjected to 2 weeks of pulsatile left heart bypass followed by 4 weeks of continuous flow left heart bypass (group CF). After autopsy, the kidneys underwent pathological evaluation. Six normal healthy goats were used as controls. The media of the afferent arterioles of group CF were frequently thickened by an increase in the number of the mature smooth muscle cells (SMCs). The juxtaglomerular areas (JGA) were expanded because of an increase in the number and size of SMCs and/or SMC-like cells. Furthermore, the percentage of anti-proliferating cell nuclear antigen antibody-positive cells in the JGA of group CF (9.9 +/- 1.9%) was significantly higher (p = 0.025) than that of the control group (4.6 +/- 3.4%), indicating active proliferation in group CF. We concluded that prolonged continuous flow left heart bypass causes proliferation of SMCs and/or SMC-like cells in the afferent arterioles and their perivascular tissue.
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Ohnishi et al. (2002) studied this question. Prolonged continuous flow left heart bypass vs. Normal healthy controls was evaluated on Percentage of anti-proliferating cell nuclear antigen antibody-positive cells in the juxtaglomerular areas (p=0.025). Prolonged continuous flow left heart bypass in goats significantly increased the percentage of proliferating cells in the juxtaglomerular areas compared to healthy controls (9.9% vs 4.6%, p=0.025).
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