Why the study?
Does prolonged nonpulsatile left heart bypass alter vascular tonus and contractility in adult goats compared to pulsatile bypass?
Population
3 adult goats undergoing left heart bypass
Comparison
Nonpulsatile left heart bypass using a… vs Pulsatile left heart bypass using a pulsatile…
Design
Preclinical
Follow-up
4 weeks
Authors
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Nonpulsatile LHB impairs vascular contractility in goats; hypothesis-generating for pulsatility effects on human vascular tone.
Does prolonged nonpulsatile left heart bypass alter vascular tonus and contractility in adult goats compared to pulsatile bypass?
Prolonged nonpulsatile left heart bypass diminishes vascular contractility without affecting baseline vascular tonus in an adult goat model.
Nishimura et al. (1999) studied this question.
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