Key result
Nonpulsatile left heart bypass with reduced pulse pressure did not significantly change cerebral metabolism compared to pulsatile left heart bypass in awake goats.
Why the study?
Does nonpulsatile left heart bypass alter cerebral metabolism compared to pulsatile left heart bypass in awake goats?
Population
9 awake goats
Comparison
Nonpulsatile left heart bypass (LHB) for 4 weeks vs Pulsatile left heart bypass for 2 weeks
Design
Preclinical
Follow-up
6 weeks (2 weeks pulsatile followed by 4 weeks nonpulsatile)
Authors
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Supports cerebral metabolic tolerance to nonpulsatile flow in goats; leaves open human LVAD translation.
Does nonpulsatile left heart bypass alter cerebral metabolism compared to pulsatile left heart bypass in awake goats?
p-value: p=NS
Prolonged nonpulsatile left heart bypass does not appear to alter cerebral metabolism compared to pulsatile bypass in an animal model.
Nishinaka et al. (2000) studied Left heart bypass (n=9). Nonpulsatile left heart bypass vs. Pulsatile left heart bypass was evaluated on Cerebral metabolism (arterio-jugular venous oxygen differences, cerebral oxygen extraction ratio, glucose differences, lactate differences) (p=NS). Nonpulsatile left heart bypass with reduced pulse pressure did not significantly change cerebral metabolism compared to pulsatile left heart bypass in awake goats.
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