Key result
Long-term nonpulsatile left heart bypass in goats increased cardiac autonomic nervous activity, with mean R-R intervals increasing from 511 ms during pulsatile bypass to 692 ms.
Authors
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Does not support changing LVAD pulsatility in patients; hypothesis-generating for autonomic effects in humans.
Absolute Event Rate: 692% vs 511%
Nishinaka et al. (1999) studied this question. Nonpulsatile left heart bypass (NLHB) vs. Pulsatile left heart bypass (PLHB) was evaluated on Mean R-R interval. Long-term nonpulsatile left heart bypass in goats increased cardiac autonomic nervous activity, with mean R-R intervals increasing from 511 ms during pulsatile bypass to 692 ms.
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